Research Topic · Peer-Reviewed

Autoimmune Diseases

Autoimmune diseases are disorders in which the adaptive immune system loses tolerance to self-antigens and mounts a sustained response against the body's own cells, tissues, and organs. They arise from a convergence of genetic susceptibility, most prominently within the major histocompatibility complex, and environm…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 50× across the literature 🔖 ISSN 3070-3360 🗓 Reviewed June 2026

Overview

Autoimmune diseases are disorders in which the adaptive immune system loses tolerance to self-antigens and mounts a sustained response against the body's own cells, tissues, and organs. They arise from a convergence of genetic susceptibility, most prominently within the major histocompatibility complex, and environmental triggers such as infection, drug exposure, and chronic inflammation, which together drive the breakdown of central and peripheral tolerance. The resulting injury is mediated by autoreactive T lymphocytes, autoantibodies, immune-complex deposition, and dysregulated cytokine signaling. Conditions are commonly classified as organ-specific, where damage is confined to a single tissue such as the thyroid, pancreatic islets, or platelets, or systemic, where multiple organ systems are affected. Clinical hallmarks include persistent inflammation, tissue destruction, and relapsing-remitting courses. Work in this area examines the genetic and inflammatory determinants of autoimmunity, overlap syndromes such as autoimmune polyglandular presentations, immune thrombocytopenia, and immune sequelae following vaccination, alongside the laboratory diagnostics and immunomonitoring methods used to detect autoantibodies and characterize immune status. Understanding these mechanisms underpins efforts to diagnose autoimmune disease earlier, distinguish overlapping presentations, and develop targeted immunomodulatory strategies that restore tolerance while limiting collateral immune suppression.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 12 articles above have been cited 50 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Autoimmune Diseases, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Complementary Medicine (ISSN 3070-3360).

This page summarises published research for orientation; it is not medical or professional advice.