2022
Overview
Monolayer cultures are a fundamental form of cell culture in which cells grow as a single layer attached to a flat surface, such as the bottom of a plastic dish or flask, rather than in suspension or in three dimensions. This two-dimensional arrangement allows cells to be observed, manipulated, and tested under controlled conditions, and it is widely used to study cell growth, behaviour, and responses to drugs and other stimuli. Monolayer culture is a workhorse technique in cell biology, cancer research, toxicology, and drug discovery, valued for its reproducibility and simplicity, though researchers increasingly compare it with three-dimensional systems that better mimic tissue architecture. This page gathers peer-reviewed, open-access research relevant to monolayer and in vitro cell culture published in the International Journal of Cell and related OpenAccessPub journals. On-topic work includes a study on the evolution of solid human tumour cell properties across various experimental systems in vitro, which examines how cancer cells behave and change under different culture conditions, a question directly connected to the use and limitations of monolayer and other culture models. Together with the journal's broader coverage of cell biology, this material reflects the role of cultured cells as experimental systems for studying cellular function and disease.
Research published in this journal
2 peer-reviewed articles, ranked by relevance. Each links to its DOI.
2015
How this research is being cited
The 2 articles above have been cited 4 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2023 · Siberian Journal of Oncology
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2023 · Siberian journal of oncology
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2022 · Effective Pharmacotherapy
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2015 · Journal of Evolving Stem Cell Research
A sample of recent works citing this journal's research on Monolayer Cultures, linking to each citing work.