Multidrug resistance (MDR) is the ability of a pathogen, such as a bacterium, or of a cancer cell to survive exposure to and become tolerant of several structurally distinct drugs that would normally inhibit or kill it. In bacteria, multidrug resistance arises through mechanisms including chromosomal gene mutations,…
Multidrug resistance (MDR) is the ability of a pathogen, such as a bacterium, or of a cancer cell to survive exposure to and become tolerant of several structurally distinct drugs that would normally inhibit or kill it. In bacteria, multidrug resistance arises through mechanisms including chromosomal gene mutations, the acquisition of resistance genes via mobile genetic elements, enzymatic inactivation of antibiotics, altered drug targets, and the loss or modification of membrane permeability and efflux systems. It is a central driver of antimicrobial resistance, complicating the treatment of common and serious infections and narrowing the range of effective therapeutic options. Research published in the International Journal of Antibiotic Research examines several facets of this problem, including the characterization of rpoB gene mutations linked to rifampicin resistance in multidrug-resistant tuberculosis patients co-infected with HIV in southern India, the genotypic diversity of Salmonella Typhi isolates from children in Nairobi, the rising threat of carbapenem resistance and antibiotic susceptibility patterns among Klebsiella pneumoniae in a tertiary care hospital, and the detection of carbapenem resistance mechanisms in avian pathogenic Escherichia coli from broiler chickens. This page gathers peer-reviewed, open-access research relevant to multidrug resistance.
10 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 10 articles above have been cited 23 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Multidrug Resistance, linking to each citing work.