Research Topic · Peer-Reviewed

Pathophysiology

Pathophysiology is the study of the functional changes that accompany disease or injury, bridging normal physiology and clinical medicine by explaining how disturbed molecular, cellular, and organ-system processes produce signs, symptoms, and outcomes. It examines the mechanisms underlying disease initiation and pro…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 34× across the literature 🗓 Reviewed June 2026

Overview

Pathophysiology is the study of the functional changes that accompany disease or injury, bridging normal physiology and clinical medicine by explaining how disturbed molecular, cellular, and organ-system processes produce signs, symptoms, and outcomes. It examines the mechanisms underlying disease initiation and progression, including dysregulated signalling, inflammation, ischaemia, genetic mutation, and metabolic derangement, and links these to prognosis and rational therapy. The research themes reflected here illustrate this breadth across organ systems: cardiac physiology and its alteration after menopause, frailty and immune dysfunction, and signalling pathways in heart failure and ischaemic heart disease. Molecular mechanisms feature prominently, including microRNA regulation in hypertension and cardiac disease, hepcidin and iron handling in anaemia of chronic kidney disease, and inherited mutations in coagulation factors that produce bleeding disorders. Further work addresses adipose-tissue physiology in obesity, immune thrombocytopenia, and rare febrile and neurological syndromes. Across these topics, pathophysiological reasoning connects underlying biology to diagnostic laboratory findings and treatment strategy. The discipline is foundational to anaesthesia and perioperative medicine, where understanding altered organ function guides safe management. The journal publishes peer-reviewed studies, mechanistic analyses, and clinical reviews that elucidate the pathophysiological basis of disease and its implications for diagnosis, monitoring, and intervention.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2017

Frailty and the Immune System

Wilson DaisyCorresponding author
Institute of Ageing and Inflammation, University of Birmingham, Edgbaston, Birmingham, UK, B15 2GW
Exact topic Aging Research And Healthcare Cited by 19 doi:10.14302/issn.2474-7785.jarh-17-1578
2019

A Rare Cause of Fever of Unknown Origin: Reverse Shapiro’s Syndrome

Gedik HabipCorresponding author
Department of Infectious Diseases and Clinical Microbiology, Ministry of Health Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
Exact topic Preventive Medicine And Care Cited by 2 doi:10.14302/issn.2474-3585.jpmc-19-2655

How this research is being cited

The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Pathophysiology, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Anesthesia.

Journal editorial board
John Bebawy · United States Pradipta Bhakta · Ireland Mainul Haque · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.