Research Topic · Peer-Reviewed

Apoptosis

Apoptosis is programmed cell death, a tightly regulated, energy-dependent process by which cells dismantle themselves in an orderly fashion without provoking inflammation. It is essential to development, tissue homeostasis, and the selection and clearance of immune cells, and its dysregulation contributes to cancer,…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 85× across the literature 🔖 ISSN 2577-137X 🗓 Reviewed June 2026

Overview

Apoptosis is programmed cell death, a tightly regulated, energy-dependent process by which cells dismantle themselves in an orderly fashion without provoking inflammation. It is essential to development, tissue homeostasis, and the selection and clearance of immune cells, and its dysregulation contributes to cancer, degenerative disease, and tissue injury. Two principal pathways converge on execution. The intrinsic, mitochondrial pathway is governed by the BCL-2 protein family, whose pro-apoptotic members such as BAK and BAX and anti-apoptotic members such as BCL-2 control mitochondrial outer-membrane permeabilization, cytochrome c release, and apoptosome formation in response to DNA damage, oxidative stress, and growth-factor withdrawal. The extrinsic pathway is triggered by ligation of cell-surface death receptors. Both pathways activate the caspase cascade, initiator and effector cysteine proteases that cleave structural and regulatory substrates, producing the characteristic hallmarks of chromatin condensation, DNA fragmentation, cell shrinkage, membrane blebbing, and apoptotic-body formation. Resistance to apoptosis, for example to butyrate-induced death in colorectal cancer, sustains tumor survival, whereas pro-apoptotic stimuli including oxidative stress and engineered nanoparticles such as silver nanoparticles can drive cancer-cell death. The journal publishes peer-reviewed research on BCL-2 and BAK regulation, oxidative-stress-induced apoptosis, apoptosis in stored platelets, and apoptotic responses in cancer and metastasis.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 85 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Apoptosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Immunization (ISSN 2577-137X).

Journal editorial board
Giuseppe Murdaca · Italy Harunor Rashid · Australia Ming Tan · United States

This page summarises published research for orientation; it is not medical or professional advice.