Research Topic · Peer-Reviewed

Tumor Stem Cells

Tumor stem cells, commonly termed cancer stem cells, are a subpopulation of malignant cells that possess the defining stem-cell properties of self-renewal and the capacity to differentiate into the heterogeneous cell types that constitute a tumour. According to the cancer stem-cell model, these cells sit at the apex…

Curated from this journal's research 📚 8 peer-reviewed articles cited Cited 10× across the literature 🔖 ISSN 2372-6601

Overview

Tumor stem cells, commonly termed cancer stem cells, are a subpopulation of malignant cells that possess the defining stem-cell properties of self-renewal and the capacity to differentiate into the heterogeneous cell types that constitute a tumour. According to the cancer stem-cell model, these cells sit at the apex of a tumour's cellular hierarchy and are responsible for initiating and sustaining tumour growth, seeding metastases, and repopulating the tumour after treatment. Their biological characteristics, including relative quiescence, enhanced DNA-repair capacity, active efflux of drugs, and resistance to apoptosis, are thought to underlie therapeutic resistance and disease relapse following conventional chemotherapy and radiotherapy that eliminate the bulk tumour but spare the stem-cell compartment. Whether cancer stem cells represent a fixed lineage or a plastic state that ordinary tumour cells can enter, and how they relate to the broader concept of field cancerization in which a tissue is primed toward malignancy, remain active questions in oncology. Cancer stem cells are typically identified by surface markers, functional assays of sphere formation, and xenotransplantation, the gold-standard test of tumour-initiating ability. Because they are implicated in initiation, progression, and resistance, cancer stem cells are an important focus of haematological and oncological research aimed at therapies that target the cells driving tumour persistence rather than only the proliferating mass.

Research published in this journal

8 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 8 articles above have been cited 10 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Tumor Stem Cells, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Krzysztof Roszkowski · Poland Agnieszka Żyromska · Poland Almuradova Dilbar Muradovna · Uzbekistan

This page summarises published research for orientation; it is not medical or professional advice.