Research Topic · Peer-Reviewed

Tumor Microenvironment

The tumor microenvironment is the complex, dynamic milieu surrounding cancer cells, comprising the surrounding non-malignant cells, blood and lymphatic vessels, immune and inflammatory cells, signaling molecules, and the extracellular matrix that together influence tumor behavior. Rather than acting in isolation, ma…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 42× across the literature 🔖 ISSN 2372-6601

Overview

The tumor microenvironment is the complex, dynamic milieu surrounding cancer cells, comprising the surrounding non-malignant cells, blood and lymphatic vessels, immune and inflammatory cells, signaling molecules, and the extracellular matrix that together influence tumor behavior. Rather than acting in isolation, malignant cells continuously interact with this environment, which can promote or constrain tumor growth, invasion, metastasis, and response to therapy. The tumor microenvironment is a major focus of hematology and oncology research because its cellular and molecular components shape cancer development and offer targets for diagnosis and treatment. Key aspects include angiogenesis and vascular signaling, immune surveillance and immunomonitoring, inflammatory infiltration, and the metabolic adaptations of tumor cells. Research in this area examines the properties of solid human tumor cells across experimental in vitro systems, the relationship between inflammatory infiltrate and mammary carcinoma, and lactate dehydrogenase as a marker of disease growth in lymphoma. Reported studies also address immunoassays and immunogenomic approaches for immunomonitoring cancer, the role of specific genes and markers such as neuropilin-1 in tumor formation and leukemogenesis, epithelial-mesenchymal transition and cancer stem-cell phenotypes, and pH-sensitive nanomedicine for treating gynaecological cancers. Work on high-throughput disease modeling for biomarker development further connects the microenvironment to ethical drug discovery and translational oncology.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Genes in Tumor Formation

Isolde RiedeCorresponding author
Journal of Hematology and Oncology Research Cited by 2 doi:10.14302/issn.2372-6601.jhor-19-2986

How this research is being cited

The 12 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Tumor Microenvironment, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Krzysztof Roszkowski · Poland Agnieszka Żyromska · Poland Almuradova Dilbar Muradovna · Uzbekistan

This page summarises published research for orientation; it is not medical or professional advice.