Research Topic · Peer-Reviewed

Oncogenes and Tumor Suppressors

Oncogenes and tumor suppressors are two classes of genes that play opposing roles in cancer development: oncogenes promote cell growth and division when abnormally activated, while tumor suppressor genes normally restrain cell proliferation and prevent malignant transformation. Research published in Hematology and O…

Curated from this journal's research 📚 2 peer-reviewed articles cited Cited 5× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed June 2026

Overview

Oncogenes and tumor suppressors are two classes of genes that play opposing roles in cancer development: oncogenes promote cell growth and division when abnormally activated, while tumor suppressor genes normally restrain cell proliferation and prevent malignant transformation. Research published in Hematology and Oncology Research has examined these mechanisms through molecular and cytogenetic approaches in hematologic malignancies. One study investigated a novel chromosomal translocation in pediatric precursor-B-acute lymphoblastic leukemia, employing molecular cytogenetic techniques to characterize the structural abnormality and its potential implications for gene disruption and leukemogenesis. Another investigation explored the regulatory control of OCT4, a gene associated with stem cell pluripotency and implicated in various cancers, by examining how microRNA-1285 might directly target and regulate its promoter region. Understanding the molecular alterations that activate oncogenes or inactivate tumor suppressors remains essential for cancer biology, as these changes drive the transformation of normal cells into malignant ones. Such research contributes to the broader effort to identify specific genetic and epigenetic mechanisms underlying blood cancers and other malignancies, providing foundational knowledge that may inform diagnostic approaches and therapeutic strategies.

Research published in this journal

2 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 2 articles above have been cited 5 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Oncogenes and Tumor Suppressors, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.