Myeloma Cells

Overview

Myeloma cells are malignant plasma cells that proliferate clonally within the bone marrow and give rise to multiple myeloma, a cancer of the terminally differentiated B-lymphocyte lineage. Derived from a single transformed plasma cell, they typically secrete a monoclonal immunoglobulin or free light chain, the paraprotein detectable in serum or urine, and depend on supportive interactions with the marrow microenvironment for survival and expansion. Their accumulation suppresses normal haematopoiesis and disrupts bone homeostasis, producing the characteristic features of anaemia, osteolytic bone disease and pathological fracture, hypercalcaemia, renal impairment, and susceptibility to infection. Myeloma cells are genomically heterogeneous, harbouring recurrent chromosomal translocations, copy-number changes, and subclonal evolution that drive disease progression and treatment resistance. Related plasma cell disorders illustrate the spectrum of this biology, including extramedullary and extraosseous plasmacytoma, plasma cell pleocytosis, and the lymphoplasmacytic proliferation of Waldenström's macroglobulinaemia. Research on myeloma cells addresses their pathogenesis, the mobilisation and collection of autologous stem cells for transplantation, complications of marrow involvement, and the development of targeted, immunomodulatory, and immune-based therapies. Characterising the molecular dependencies and microenvironmental signals that sustain myeloma cells remains central to improving diagnosis, risk stratification, and durable disease control in this incurable but increasingly treatable malignancy.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 9 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Intrathyroidal Plasmacytoma with Pleomorphic Multilobated Bizarre Cells: A Rare Primary Clinicopathological Presentation Mimicking Anaplastic Carcinoma of Thyroid
  2022 · Head and Neck Pathology
• Intrathyroidal Plasmacytoma with Pleomorphic Multilobated Bizarre Cells: A Rare Primary Clinicopathological Presentation Mimicking Anaplastic Carcinoma of Thyroid
  2022 · Head and Neck Pathology
• Polyclonal Immunotactoid Glomerulopathy Associated with Monoclonal Gammopathy of IgM Type and Underlying Plasmacellular Disease: Successful Treatment with Rituximab Alone
  Wolfgang Neukirchen et al. · 2022 · Case Reports in Nephrology and Dialysis
• Generating Accurate Caption Units for Figure Captioning
  2021 ·
• Adversarial Image Caption Generator Network
  2021 · SN Computer Science
• A rare case of MGRS with immunotactoid glomerulopathy responding to bortezomib, dexamethasone, and rituximab
  2020 · Clinical Case Reports
• A Formative Study on Designing Accurate and Natural Figure Captioning Systems
  2020 ·
• A Formative Study on Designing Accurate and Natural Figure Captioning Systems
  Xin Qian et al. · 2020 · CHI Extended Abstracts

A sample of recent works citing this journal's research on Myeloma Cells, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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