Virginia Bioinformatics Institute
1015 Life Science Circle
Blacksburg, VA 24061-0477
- The primary research interest of Xie's group is to understand the molecular mechanisms underlying epigenetic transitions during important biological processes associated with human complex diseases.
- Toward this goal, my group emphasizes the development of high-throughput sequencing approaches for data generation and the implementation of computational tools for -omics data analysis.
- In particular, the group is interested in strategies to monitor the fidelity of DNA methylation inheritance, assess methylation variation within and between cell populations, identify true epimutations, and, eventually, discover novel therapies.
- Our previous studies include bio-technique development to facilitate targeted epigenome sequencing, CpG islands and Alu repeats in particular ; and model establishment to assess DNA methylation variations and simulate epigenetic state transitions during stem cell differentiation, reprogramming and disease genesis.
- We have successfully applied techniques and bioinformatics tools to identify diagnosis markers for diseases.
- Dr. Hehuang Xie graduated from the University of Iowa with Ph.D. in genetics and a master degree in computer science in 2003.
- After his graduate studies, Dr. Xie received his postdoctoral training in the field of bioinformatics at The University of Iowa and The University of Minnesota.
- In 2005, Dr. Xie joined the Cancer Biology and Epigenomics Program, Children Memorial Research Center;
- Department of Pediatrics, Northwestern University as a research faculty.
- Currently, Dr. Xie is an associate professor at the Virginia Bioinformatics Institute.