Research Topic · Peer-Reviewed

Hematopoiesis

Hematopoiesis is the process by which the body produces and continuously replenishes its blood cells, generating erythrocytes, leukocytes, and platelets from a small population of self-renewing hematopoietic stem cells. In adults it occurs mainly in the bone marrow, where stem cells give rise to multipotent and line…

Curated from this journal's research 📚 5 peer-reviewed articles cited Cited 21× across the literature 🔖 ISSN 2372-6601

Overview

Hematopoiesis is the process by which the body produces and continuously replenishes its blood cells, generating erythrocytes, leukocytes, and platelets from a small population of self-renewing hematopoietic stem cells. In adults it occurs mainly in the bone marrow, where stem cells give rise to multipotent and lineage-committed progenitors that proliferate and differentiate along the myeloid and lymphoid pathways under the control of transcription factors, cytokines, and growth factors such as erythropoietin, together with signals from the supporting marrow microenvironment. This tightly regulated hierarchy balances stem-cell maintenance against the demand for mature, functional blood cells throughout life. Disruption of hematopoiesis underlies a wide range of disorders relevant to hematology and oncology: clonal genetic and chromosomal abnormalities can drive leukemias and related malignancies, aberrant signaling can transform marrow function as in myeloproliferative disease, and toxic or therapeutic insults can selectively impair specific lineages, as when certain chemotherapeutic agents suppress red-cell production or provoke resistance to erythropoietin and immune dysfunction. Investigation of hematopoiesis employs molecular, cytogenetic, and cellular approaches to define normal lineage commitment and to characterize the mutations, marker expression, and microenvironmental factors that govern blood formation and its failure. Understanding these mechanisms informs the diagnosis and classification of blood diseases and the development of therapies that protect, restore, or redirect blood-cell production in both benign and malignant conditions.

Research published in this journal

5 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 5 articles above have been cited 21 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Hematopoiesis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Krzysztof Roszkowski · Poland Agnieszka Żyromska · Poland Almuradova Dilbar Muradovna · Uzbekistan

This page summarises published research for orientation; it is not medical or professional advice.