Research Topic · Peer-Reviewed

Factor V Leiden

Factor V Leiden is a genetic mutation that increases the risk of developing blood clots, also known as thrombophilia. Normally, factor V is a protein that helps blood clot when there is an injury. However, the mutation causes factor V to be resistant to the normal inhibition by protein C, and this results in excess …

Curated from this journal's research 📚 3 peer-reviewed articles cited Cited 3× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Factor V Leiden is a genetic mutation that increases the risk of developing blood clots, also known as thrombophilia. Normally, factor V is a protein that helps blood clot when there is an injury. However, the mutation causes factor V to be resistant to the normal inhibition by protein C, and this results in excess formation of blood clots. Factor V Leiden is inherited in an autosomal dominant pattern, meaning that only one copy of the gene is needed for a person to develop this condition. It is most common among people of European descent, with a prevalence of around 5%. Individuals with factor V Leiden have an increased risk of developing deep vein thrombosis (DVT) and pulmonary embolism (PE), which are potentially life-threatening conditions. Some studies have also shown an increased risk of other thrombotic events such as stroke, heart attack, and pregnancy loss. Diagnosis of factor V Leiden is typically made through a blood test. Treatment may involve blood-thinning medication to help prevent the formation of blood clots. Lifestyle changes such as regular exercise, maintaining a healthy weight, and avoiding smoking can also help reduce the risk of blood clots. Overall, it is important for individuals with a family history of factor V Leiden or those who have experienced blood clots to speak with their healthcare provider and undergo appropriate testing and treatment to prevent potentially serious complications.

Research published in this journal

3 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 3 articles above have been cited 3 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Factor V Leiden, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.