Cerebrovascular diseases are disorders of the blood vessels supplying the brain that disrupt cerebral blood flow and thereby cause neurological injury or dysfunction. They encompass ischaemic events, in which arterial occlusion or critical hypoperfusion deprives brain tissue of oxygen and glucose, and haemorrhagic e…
Cerebrovascular diseases are disorders of the blood vessels supplying the brain that disrupt cerebral blood flow and thereby cause neurological injury or dysfunction. They encompass ischaemic events, in which arterial occlusion or critical hypoperfusion deprives brain tissue of oxygen and glucose, and haemorrhagic events, in which a vessel ruptures within or around the brain, as well as chronic small-vessel disease that contributes to cognitive decline. Stroke, the acute clinical expression of these processes, is subdivided into ischaemic and haemorrhagic types, and different stroke subtypes are associated with distinct patterns of vascular and endothelial dysfunction. The integrity of the cerebral vasculature depends on endothelial function and on systemic vascular risk, so cerebrovascular disease shares major risk factors with cardiovascular disease, including hypertension, diabetes, dyslipidaemia, smoking, and raised homocysteine; carotid intima-media thickness and endothelial reactivity serve as markers of this shared vascular burden. Smoking and vaping, salt overconsumption, obesity, and depressive symptoms in vulnerable populations further interact with these pathways to influence vascular health. Mechanistically, oxidative stress and impaired vasoprotection are implicated in vascular injury, and antioxidant and neuroprotective strategies are investigated experimentally. Because cerebrovascular disease is a leading cause of death and long-term disability, its study spans prevention through risk-factor control, acute management of stroke, and rehabilitation, linking vascular biology with clinical neurology.
8 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 8 articles above have been cited 49 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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