Research Topic · Peer-Reviewed

Crohn Disease

Crohn disease is a chronic, relapsing form of inflammatory bowel disease characterized by transmural inflammation that can affect any segment of the gastrointestinal tract from mouth to anus, most often the terminal ileum and colon, typically in a discontinuous pattern. Its inflammation is full-thickness and can be …

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 39× across the literature 🔖 ISSN 2997-1977 🗓 Reviewed July 2026

Overview

Crohn disease is a chronic, relapsing form of inflammatory bowel disease characterized by transmural inflammation that can affect any segment of the gastrointestinal tract from mouth to anus, most often the terminal ileum and colon, typically in a discontinuous pattern. Its inflammation is full-thickness and can be granulomatous, predisposing to complications such as strictures, fistulas, and abscesses that distinguish it from ulcerative colitis. The disease arises from a dysregulated mucosal immune response to gut microbes in genetically susceptible individuals, shaped by environmental and dietary factors. Clinical features include abdominal pain, chronic diarrhea, weight loss, and extraintestinal manifestations, with a course of flares and remissions. Diagnosis integrates clinical, endoscopic, histopathological, and imaging findings, including magnetic resonance enterography and computed tomography to assess disease extent, activity, and complications. Management is not curative but aims to induce and maintain remission through medical therapy, nutritional and dietary intervention, and surgery for refractory or complicated disease. Research relevant to this topic includes magnetic resonance enterography in the diagnosis of Crohn disease, models for identifying actionable computed-tomography findings in the emergency setting, the clinicopathologic analysis of granulomatous gastritis, dietary and elemental nutrition approaches in gastrointestinal disease, and candidate adjuncts such as capsaicin for inflammatory bowel disease.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Crohn Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Diseases (ISSN 2997-1977).

Journal editorial board
Madalena Barroso · Germany VASSILIKI PITIRIGA · Greece Andrzej Prystupa · Poland

This page summarises published research for orientation; it is not medical or professional advice.