Tandem mass spectrometry, often written as MS/MS, is an analytical technique that uses two or more stages of mass analysis to identify and quantify molecules in complex samples. After a molecule is ionized and selected by its mass-to-charge ratio in the first stage, it is fragmented and the resulting pieces are meas…
Tandem mass spectrometry, often written as MS/MS, is an analytical technique that uses two or more stages of mass analysis to identify and quantify molecules in complex samples. After a molecule is ionized and selected by its mass-to-charge ratio in the first stage, it is fragmented and the resulting pieces are measured in a second stage. The fragmentation pattern provides detailed structural information, allowing molecules of similar mass to be distinguished and trace components to be detected with high sensitivity and specificity. This makes MS/MS a core tool in proteomics, metabolomics, pharmaceutical analysis, and clinical and food testing. Within this journal's mass spectrometry scope, research applies tandem mass spectrometry to a range of analytical problems. Reported work includes the optimization and analysis of affinity purification coupled with tandem mass spectrometry in mammalian cells, sensitive liquid chromatography–tandem mass spectrometry methods for determining a compound in rat plasma, and a tandem mass spectrometry method developed to support a bioequivalence study by measuring a drug in human plasma. These studies illustrate how MS/MS supports precise identification and quantification. This page gathers peer-reviewed, open-access research relevant to tandem mass spectrometry and its analytical applications.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 115 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Tandem Mass Spectrometry, linking to each citing work.