Chromatography Mass Spectrometry

Overview

Chromatography-mass spectrometry is a family of hyphenated analytical techniques that couples a chromatographic separation with mass-spectrometric detection so that the components of a complex mixture are first separated and then identified and quantified according to their mass-to-charge ratios. The approach unites two complementary measurements: chromatography (most commonly liquid chromatography, LC, or gas chromatography, GC) resolves a sample into its constituent compounds in time, while the mass spectrometer records the masses of the eluting molecules and their fragments, providing both structural information and sensitive quantitation. The two principal configurations, LC-MS and GC-MS, suit different analyte classes; tandem arrangements (MS/MS) add a second stage of mass selection to improve specificity in trace analysis. Because it can detect and measure compounds at very low concentrations within complicated matrices, chromatography-mass spectrometry is central to analytical chemistry, pharmaceutical bioanalysis, toxicology, food safety, environmental monitoring, and metabolite and isotope studies. Recurring methodological themes include method development and validation, identification and quantification of target analytes, detection of adulterants and contaminants of emerging concern, and the determination of isotopic abundance ratios. Research published in this area reflects these applications, including LC-MS and GC-MS studies of drugs in plasma for bioequivalence work, detection of adulterants in dietary supplements, food-safety reviews, and characterization of pharmaceutical substances.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Metabolomics of Trichoderma spirale by Mass Spectrometry Data Dereplication
  2025 · Chemistry of Natural Compounds
• Pharmacokinetic Simulation and Area under the Curve Estimation of Drugs Subject to Enterohepatic Circulation
  Melchor Alpízar et al. · 2024 · Pharmaceutics
• Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasma.
  U. Thorsteinsdóttir et al. · 2024 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
• Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements
  Oana Ramona Cătălina Gheorghiu et al. · 2023 · Molecules
• Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements
  2023 · Molecules
• First Chemical Profile Analysis of Acacia Pods
  2023 · Plants
• LC/HRESI-MS/MS screening, phytochemical characterization, and in vitro antioxidant and cytotoxic potential of Jatropha integerrima Jacq. extracts
  2023 · Bioorganic Chemistry
• Synthesis, characterization and in vitro cytotoxicity of ruthenium(II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 cells.
  Caio Cesar Candido et al. · 2022 · Journal of Inorganic Biochemistry

A sample of recent works citing this journal's research on Chromatography Mass Spectrometry, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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