Epidermal growth factor (EGF) is a small signaling polypeptide that binds the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, to stimulate cell proliferation, migration, differentiation, and survival. Receptor engagement triggers dimerization, autophosphorylation, and activation of downstream ca…
Epidermal growth factor (EGF) is a small signaling polypeptide that binds the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, to stimulate cell proliferation, migration, differentiation, and survival. Receptor engagement triggers dimerization, autophosphorylation, and activation of downstream cascades such as RAS-MAPK and PI3K-AKT that drive epithelial and mesenchymal cell responses. EGF signaling is central to tissue repair and wound healing, epithelial maintenance, and angiogenesis, and its dysregulation, through receptor overexpression or activating mutations, contributes to carcinogenesis, making the EGFR axis a major target of anticancer therapeutics. Pharmacological inhibitors of this pathway, including small-molecule tyrosine-kinase inhibitors, produce characteristic cutaneous and adnexal effects that reflect the receptor's role in skin biology. Research relevant to this area examines wound-fluid influences on healing in three-dimensional wound models, amniotic-membrane treatment of severe cutaneous injury, EGFR-inhibitor-associated trichomegaly, proteomic responses to EGFR-targeted agents such as lapatinib, and growth-factor signaling in tissue engineering and tumor biology. The journal publishes peer-reviewed studies on growth-factor signaling, receptor-mediated regulation of cell behavior, wound healing and tissue repair, and the role of the EGF/EGFR axis in epithelial maintenance and disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 48 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Epidermal Growth Factor, linking to each citing work.