Depressions, Therapy-resistant

Depressions, therapy-resistant, is a type of major depressive disorder (MDD) that does not respond to conventional treatments like antidepressants, talk therapy, and lifestyle changes. This chronic form of depression can affect a person's ability to function in everyday life and can cause serious physical and emotional health issues. The causes of therapy-resistant depressions are not completely understood, but research indicates that it is related to an imbalance in the brain chemistry. Treatment options for this type of depression include medications, electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), and psychotherapy. Other therapies, such as cognitive-behavioral therapy and interpersonal therapy, have also been effective in some cases. With the proper diagnosis and treatment, therapy-resistant depression can be managed and recovery can be achieved.