Overview
Viremia is the presence of virus particles circulating in the bloodstream, a state that reflects active viral replication and dissemination from the initial site of infection to distant tissues. It is quantified as viral load, the concentration of viral genomes or particles per unit volume of blood, which serves as a central biomarker of disease activity and of the response to antiviral therapy. In HIV infection the magnitude of viremia tracks disease progression and transmissibility, and durable suppression of plasma viral load to undetectable levels is the explicit goal of antiretroviral treatment, achieved through combinations that include nucleoside and nucleotide reverse transcriptase inhibitors. Persistent or rebounding viremia signals incomplete suppression and is closely linked to the emergence of drug-resistant viral variants, particularly where adherence is imperfect or regimens are suboptimal, a concern documented in treatment-experienced children and adolescents. Quantifying viremia also informs prognosis in acute viral syndromes and supports risk stratification in severe respiratory infection. Distinct from primary versus secondary viremia, which describe successive waves of bloodstream invasion, the clinical value of viral-load measurement lies in monitoring trajectory over time. Research examines resistance patterns, the relationship between viral kinetics and outcome, and the laboratory methods used to detect and quantify circulating virus.
Research published in this journal
5 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Validity of PIRO Score as an Assessment Tool for Mortality Risk of COVID-19 Pneumonia among Patients Admitted to World Citi Medical Center from March to August 2020. A Retrospective Observational Cohort Study
Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Induce Aging by Inhibiting Telomerase Function
SARS-Cov-2 Viral Kinetics in Mild COVID-19 Patients Treated with Chloroquine Regimens or Standard of Care
How this research is being cited
The 5 articles above have been cited 2 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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JoAnn P. Pfeiffer et al. · 2015 · Therapeutic Innovation and Regulatory Science
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2014 · Therapeutic Innovation & Regulatory Science
A sample of recent works citing this journal's research on Viremia, linking to each citing work.