Research Topic · Peer-Reviewed

HIV/AIDS and Gene Therapy

HIV/AIDS and gene therapy denotes the application of genetic approaches to treat, control, or potentially cure human immunodeficiency virus infection by modifying host or immune-cell genomes rather than relying solely on lifelong pharmacologic suppression. Conceptually, strategies include disrupting entry coreceptor…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 21× across the literature 🔖 ISSN 2324-7339 🗓 Reviewed July 2026

Overview

HIV/AIDS and gene therapy denotes the application of genetic approaches to treat, control, or potentially cure human immunodeficiency virus infection by modifying host or immune-cell genomes rather than relying solely on lifelong pharmacologic suppression. Conceptually, strategies include disrupting entry coreceptors, engineering HIV-resistant immune cells, delivering antiviral transgenes, and harnessing gene-edited cells to reconstitute durable immunity, with the goal of achieving sustained remission off antiretroviral therapy. This sits against the established backdrop of combination antiretroviral and highly active antiretroviral therapy, whose limitations motivate genetic alternatives: adverse drug reactions, the cost and burden of adverse events, long-term toxicities, and the challenge of treatment adherence. Related investigative threads include the cellular consequences of reverse transcriptase inhibitors, dual-target antiviral concepts, and adjunctive or phytochemical interventions explored for their immunological effects in seropositive individuals. Clinical profiles of HIV-infected patients in the antiretroviral era, including comorbidities such as bone loss in relation to CD4 status, frame the unmet needs that curative genetic strategies aim to address. The peer-reviewed research gathered here concentrates on antiretroviral pharmacology, drug safety, adherence, and the clinical course of HIV infection, providing the therapeutic context within which gene-based approaches to HIV and AIDS are evaluated.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2012

Dual Choice for Dual Target Anti-HIV Therapy

Marchand ChristopheCorresponding author
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda
Clinical Research In HIV AIDS And Prevention Cited by 1 doi:10.14302/issn.2324-7339.jcrhap-12-edt.1.1
2013

Pattern of Use of Highly Active Antiretroviral Therapy Regimens and Pattern of Occurrence of Adverse Drug Reactions in an Indian Human Immunodeficiency Virus Positive Patients

Rajesh RadhakrishnanCorresponding author
Radhakrishnan Rajesh M.Pharm, Asst Professor (Senior Grade), Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal- 576 104, Karnataka, India.
Clinical Research In HIV AIDS And Prevention Cited by 1 doi:10.14302/issn.2324-7339.jcrhap-12-174
2014

Phytochemicals May Arrest HIV-1 Progression

Sharma B.Corresponding author
Department of Biochemistry, Faculty of Science,
Clinical Research In HIV AIDS And Prevention Cited by 5 doi:10.14302/issn.2324-7339.jcrhap-13-edt.1.3

How this research is being cited

The 12 articles above have been cited 21 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on HIV/AIDS and Gene Therapy, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Clinical Research In HIV AIDS And Prevention (ISSN 2324-7339).

Journal editorial board
Manoj Sarma · United States Mohammed Merzah · Hungary Marta Talavera · Spain

This page summarises published research for orientation; it is not medical or professional advice.