HIV/AIDS and aging refers to the intersection of human immunodeficiency virus infection with the biology and clinical management of older age, encompassing both people who acquire HIV later in life and the expanding population growing older while living with the virus. Sustained antiretroviral therapy has transforme…
HIV/AIDS and aging refers to the intersection of human immunodeficiency virus infection with the biology and clinical management of older age, encompassing both people who acquire HIV later in life and the expanding population growing older while living with the virus. Sustained antiretroviral therapy has transformed HIV into a chronic condition, so attention has shifted to accelerated and accentuated aging: premature onset of comorbidities, persistent immune activation, immunosenescence, and the cumulative effects of long-term drug exposure. A recurring mechanistic theme is whether certain antiretroviral agents, particularly nucleoside and nucleotide reverse transcriptase inhibitors, contribute to cellular aging through mitochondrial toxicity and inhibition of telomerase activity, and how chronic infection compounds these processes. Cognitive health is a further focus, with work characterizing cognitive subtypes and the demographic, clinical, and psychosocial factors that shape neurocognitive trajectories in adults aging with HIV. Behavioral, psychosocial, and theoretical frameworks for supporting people living with HIV across the life course also bear on this area, alongside prevention and risk-reduction efforts relevant to older and younger cohorts alike. The peer-reviewed research collected here spans antiretroviral pharmacology, neurocognitive assessment, and the social and supportive dimensions of long-term HIV care, reflecting the multidisciplinary nature of aging in the context of HIV and AIDS.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 64 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on HIV/AIDS and Aging, linking to each citing work.