Antiretroviral therapy (ART) is the use of combinations of antiretroviral drugs to suppress replication of the human immunodeficiency virus (HIV), reducing the amount of virus in the body, preserving immune function, and lowering the risk of onward transmission. Modern regimens, sometimes described as highly active …
Antiretroviral therapy (ART) is the use of combinations of antiretroviral drugs to suppress replication of the human immunodeficiency virus (HIV), reducing the amount of virus in the body, preserving immune function, and lowering the risk of onward transmission. Modern regimens, sometimes described as highly active antiretroviral therapy (HAART), combine agents from different drug classes and have transformed HIV from a fatal infection into a manageable chronic condition. ART encompasses drug selection, adherence, monitoring of immune and virological response, and the management of toxicity and resistance. Research published by the journal addresses adverse drug reactions to antiretroviral regimens and their direct costs, the measurement of treatment adherence in resource-limited settings, and the psychosocial factors that influence whether patients maintain therapy. Other work examines drug-resistance and baseline characteristics among treatment-experienced children and adolescents, disclosure of HIV status to children receiving treatment, and modeling of CD4 cell-count change under long-term therapy. Clinical studies also consider complications and comorbidities in people living with HIV, including peripheral neuropathy associated with antiretroviral treatment, asymptomatic myocardial ischemia, and the proposed effects of nucleoside and nucleotide reverse-transcriptase inhibitors. Much of this research is set in sub-Saharan Africa and South Asia, reflecting the global distribution of the epidemic and the central role of adherence and access in determining outcomes.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Antiretroviral Therapy, linking to each citing work.