Chromatin is the macromolecular complex of DNA and associated proteins, principally histones, that packages the eukaryotic genome within the nucleus. Its fundamental repeating unit is the nucleosome, in which roughly 147 base pairs of DNA wrap around a histone octamer; nucleosomes fold into higher-order structures t…
Chromatin is the macromolecular complex of DNA and associated proteins, principally histones, that packages the eukaryotic genome within the nucleus. Its fundamental repeating unit is the nucleosome, in which roughly 147 base pairs of DNA wrap around a histone octamer; nucleosomes fold into higher-order structures that compact the genome while regulating access to the underlying sequence. Chromatin exists along a continuum from loosely packed, transcriptionally permissive euchromatin to densely condensed, generally silent heterochromatin, and its state is dynamically controlled by histone post-translational modifications, DNA methylation, ATP-dependent chromatin remodeling, and the binding of transcription factors. Through these mechanisms chromatin governs gene expression, DNA replication and repair, and the faithful transmission of genetic and epigenetic information across cell divisions, making it central to development, cellular identity, and disease. Research in related molecular and cellular biology examines transcription-factor binding sites and regulatory single-nucleotide polymorphisms, signaling pathways governing cell proliferation and differentiation, microRNA regulation, and the comparative genomics of orthologous genes. The journal publishes peer-reviewed research in molecular genetics, genomics, and cell biology in which chromatin organization, epigenetic regulation, and gene expression are studied, reflecting chromatin's foundational role in the storage, regulation, and inheritance of genetic information.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 79 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Chromatin, linking to each citing work.