Research Topic · Peer-Reviewed

Biomarker Discovery

Biomarker discovery is the systematic process of identifying biological molecules, such as proteins, nucleic acids, and metabolites, whose presence, absence, or altered level reliably indicates a particular biological state, including disease onset, progression, or response to treatment. In oncology it is foundation…

Curated from this journal's research 📚 7 peer-reviewed articles cited Cited 16× across the literature 🔖 ISSN 2572-3030 🗓 Reviewed July 2026

Overview

Biomarker discovery is the systematic process of identifying biological molecules, such as proteins, nucleic acids, and metabolites, whose presence, absence, or altered level reliably indicates a particular biological state, including disease onset, progression, or response to treatment. In oncology it is foundational to early detection, prognosis, and the selection and monitoring of therapy. The discovery workflow typically progresses from candidate identification, through analytical and clinical validation, to assay development, drawing on high-throughput technologies and increasingly on disease-modelling platforms; relevant work includes high-throughput complex-disease modelling on new-approach-methodology platforms developed for cancer biomarker development. Molecular profiling techniques are central, with proteomic and genomic methods applied to cancer diagnostics and personalised medicine, and ion-current-based proteomics used to characterise responses to targeted agents. Circulating nucleic acids are a major focus, illustrated by dynamic microRNA expression in the plasma of melanoma patients linked to progression and survival, and by microfluidic and digital-PCR assays employing microRNAs for the diagnostic screening of colon cancer, including in low-resource settings. Significance lies in translating molecular signatures into practical tests that improve patient care. Principal sub-areas include candidate identification, analytical and clinical validation, proteomic and genomic platforms, circulating and microRNA biomarkers, and the development of accessible diagnostic assays.

Research published in this journal

7 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 7 articles above have been cited 16 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Biomarker Discovery, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Cancer Genetics And Biomarkers (ISSN 2572-3030).

Journal editorial board
Dr. Charlie Gourley · United Kingdom Dr. Xinyu Chen · United States Dr. Guru Prasad Maiti · United States

This page summarises published research for orientation; it is not medical or professional advice.