Malignant tumors are neoplasms composed of cells that proliferate uncontrollably, invade adjacent tissue, and possess the capacity to metastasize to distant sites, distinguishing them from benign growths that remain localized. They arise from the accumulation of genetic and epigenetic alterations that disrupt normal…
Malignant tumors are neoplasms composed of cells that proliferate uncontrollably, invade adjacent tissue, and possess the capacity to metastasize to distant sites, distinguishing them from benign growths that remain localized. They arise from the accumulation of genetic and epigenetic alterations that disrupt normal controls on cell division, differentiation, and death, conferring sustained proliferation, evasion of apoptosis, and angiogenesis. Malignancies are classified by tissue of origin, including carcinomas from epithelium, sarcomas from connective and soft tissue, and tumors of nervous, hematologic, and glandular tissues, and are graded and staged according to differentiation, local extent, and spread. Diagnosis integrates clinical findings, imaging, and histopathologic examination, increasingly supplemented by molecular and biomarker analysis to refine classification and guide therapy. Representative work in this field spans peripheral nerve sheath tumors, leiomyosarcoma, breast and ovarian neoplasms, thyroid malignancies, and tumors of bone and the central nervous system, as well as the imaging features and differential diagnosis of soft-tissue masses. Studies also examine elemental composition of malignant tissue, biomarker identification, and the neuropsychiatric manifestations of brain tumors. Management typically combines surgery, radiation, chemotherapy, and targeted approaches, with early detection and accurate characterization remaining decisive for prognosis and treatment selection across diverse anatomic sites.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 40 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Malignant Tumors, linking to each citing work.