Research Topic · Peer-Reviewed

Neurofibrillary Tangles

Neurofibrillary tangles (NFTs) are aggregates of twisted proteins found in the brains of people with Alzheimer’s disease and other neurodegenerative diseases. NFTs are composed of the protein tau, which normally forms a scaffolding inside the cell to help stabilize its structure and transport cargoes between organel…

Curated from this journal's research 📚 2 peer-reviewed articles cited Cited 9× across the literature 🔖 ISSN 2998-4211 🗓 Reviewed July 2026

Overview

Neurofibrillary tangles (NFTs) are aggregates of twisted proteins found in the brains of people with Alzheimer’s disease and other neurodegenerative diseases. NFTs are composed of the protein tau, which normally forms a scaffolding inside the cell to help stabilize its structure and transport cargoes between organelles. Under certain conditions, however, tau becomes hyperphosphorylated and condenses into filamentous aggregates that form the NFTs. The presence of NFTs is associated with the loss of nerve cells in the brain, which leads to the cognitive decline seen in neurodegenerative diseases. NFTs are important biomarkers for the diagnosis of Alzheimer’s disease, and they are also being investigated as potential therapeutic targets.

Research published in this journal

2 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 2 articles above have been cited 9 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Neurofibrillary Tangles, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Alzheimer's Research and Therapy (ISSN 2998-4211).

Journal editorial board
Aysun Cetinyurek Yavuz · Netherlands Elvis Freeman Acquah · Australia Silvia Ingala · Denmark

This page summarises published research for orientation; it is not medical or professional advice.