Cyclophosphamide

Overview

Cyclophosphamide is a nitrogen mustard alkylating agent used as a chemotherapeutic and immunosuppressive drug. It is a prodrug, requiring hepatic activation by cytochrome P450 enzymes to form active metabolites, principally phosphoramide mustard, which cross-link DNA strands and thereby block replication and trigger death of rapidly dividing cells. Through this mechanism it is employed in the treatment of haematological malignancies such as leukaemias and lymphomas and several solid tumours, and at lower doses to suppress aberrant immune activity in autoimmune and inflammatory disorders, including the conditioning regimens used before haematopoietic stem cell transplantation. Because its cytotoxic action is not confined to tumour cells, cyclophosphamide produces dose-limiting toxicities affecting other proliferating tissues, including myelosuppression, urothelial injury, and impaired gametogenesis; experimental work has examined its capacity to inhibit spermatogenesis and induce oxidative stress, together with protective strategies against these effects. It is frequently combined with other agents in multidrug protocols to enhance efficacy and is relevant to the management of transplant-associated lymphoproliferative disorders and stem-cell mobilisation contexts. Related research addresses its role in oncology and transplantation, its reproductive and oxidative toxicity, and complementary measures intended to mitigate organ damage while preserving the drug's antineoplastic and immunomodulatory benefits.

Research published in this journal

8 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 8 articles above have been cited 24 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives
  Zahirrah Begam Mohamed Rasheed et al. · 2023 · Biology
• Urine analysis and nutrition status among elderly in Griya Werdha, Surabaya
  2023 · Journal of Public Health in Africa
• Urine analysis and nutrition status among elderly in Griya Werdha, Surabaya
  T. Mahmudiono et al. · 2023 · Journal of Public Health in Africa
• Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives
  2023 · Biology
• Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer
  Jaekwon Seok et al. · 2023 · Journal of Translational Medicine
• Mesenchymal stem cells as an adjuvant for the treatment of poi, and as a support in expectant management of placental hematomas and premature rupture of membranes: case report
  Luján Irastorza Jesús Estuardo et al. · 2022 · Obstetrics & Gynecology International Journal
• The Effect of Supplementation of Fennel (Foeniculum Vulgare Mill.) to the Feed on Egg Production, Slaughter and Carcass Characteristics, Formation of Parasites in the Intestine and Spermatological Quality in Japanese Quail During the Laying Period
  2022 · Dicle Üniversitesi Veteriner Fakültesi Dergisi
• Use of fennel seeds extract as a protector against high fructose diet-induced cardiac injury in male rats
  H. M. El-Nigomy et al. · 2022 · Mansoura Journal of Biology

A sample of recent works citing this journal's research on Cyclophosphamide, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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