Research Topic · Peer-Reviewed

Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a malignancy of immature lymphoid precursor cells, or lymphoblasts, that arise in the bone marrow and accumulate at the expense of normal hematopoiesis. It is classified by lineage into B-cell precursor and T-cell subtypes, the former being the predominant form in pediatric dise…

Curated from this journal's research 📚 5 peer-reviewed articles cited Cited 18× across the literature 🗓 Reviewed June 2026

Overview

Acute lymphoblastic leukemia (ALL) is a malignancy of immature lymphoid precursor cells, or lymphoblasts, that arise in the bone marrow and accumulate at the expense of normal hematopoiesis. It is classified by lineage into B-cell precursor and T-cell subtypes, the former being the predominant form in pediatric disease, and is further stratified by recurrent cytogenetic and molecular lesions that carry prognostic weight. Structural chromosomal rearrangements, including translocations and other balanced or unbalanced aberrations, define many subgroups, and their detection by karyotyping, fluorescence in situ hybridization, and molecular cytogenetics guides risk assignment and therapy. Surface markers such as CD antigens characterize blast phenotype and lineage, and abnormal expression of receptors implicated in leukemogenesis is studied to clarify how transformation and proliferation proceed. Because leukemic blasts circulate and infiltrate hematopoietic and lymphoid compartments, work on targeted delivery, including nucleic-acid agents directed at specific cell populations, addresses how therapeutics reach malignant cells. Diagnosis integrates morphology, immunophenotyping, and genetic analysis, while contemporary immunomonitoring approaches assess residual disease and immune response. Research spans the biology of precursor-B and T-lineage transformation, novel chromosomal abnormalities, mechanisms of relapse, and strategies to improve outcomes across pediatric and adult populations.

Research published in this journal

5 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 5 articles above have been cited 18 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Acute Lymphoblastic Leukemia, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Advances in Leukemia.

Journal editorial board
Hang Su · United States Ewelina Grywalska · Poland Antonio Ruggiero · Italy

This page summarises published research for orientation; it is not medical or professional advice.