Wistar Rats

Wistar rats are a widely used laboratory animal in advanced pharmaceutical science and technology for drug development studies. They are often preferred over other animals because they are easier to breed, handle, and maintain. These rats are highly responsive to drug-induced toxicity which makes them ideal for toxicity and safety studies in drug development. Wistar rats have also been used in a wide range of studies related to cardiovascular diseases, nervous system disorders, and genetics. Their genome is already mapped, and there is a wealth of information available on their genetic makeup, making them an ideal model for pharmacogenomics research. In drug development studies, Wistar rats are used to test the efficacy of new compounds, determine their pharmacokinetics, and identify potential drug-drug interactions. They are often used in preclinical trials to assess adverse side effects before human clinical trials. Wistar rats are highly adaptable and can tolerate changes in diet, light cycles, and other environmental factors. They are also known for their high reproductive rate, with females producing litters of up to 10 pups. This reproductive ability makes them an essential resource for researchers studying reproductive biology and toxicology. Overall, Wistar rats play an essential role in the advancement of pharmaceutical science and technology. They are widely used in preclinical studies to accelerate drug discovery and development, ultimately leading to better treatments and improved health outcomes for patients.

← Journal of Advanced Pharmaceutical Science And Technology

Related Articles

34 article(s) found

Early Glycine Supplementation Re-Establishes Adrenal Catecholamine Secretion in Hypothalamic Obesity Model in Rats but does not Affect Visceral Adiposity.

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Protective Effect of Fennel Oil on Cyclophosphamide Inhibited Spermatogenesis and Induced Oxidative Stress in Albino Rats.

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Comparative Study of Hypolipidemic Effects of Momordica Charantia (Karela) with Atorvastatin in Fat Fed Rats

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Bisphenol A Down-Regulates The mRNA Expression of Steroidogenic Genes and Induces Histopathological Changes in Testes Of Rats

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Lipopolysaccharide Prompts Oxidative Stress and Apoptosis in Rats’ Testicular Tissue

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Changes in Rats’ Liver Structure Induced by Zinc Oxide Nanoparticles and the Possible Protective Role of Vitamin E

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Beneficial Effects of Fennel (Foeniculum Vulgare) in Treating Obesity in Rats

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Interaction Between Ator and Fennel in the Treatment of Obesity in Rats

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Trigonella Foenum Graecum Extract Benefits on Hematological, Biochemical and Male Reproductive System as a Complementary Therapy with Glimepiride in Treating Streptozotocin Induced Diabetic Rats

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Exercise and Vitamin D Supplementation Modify Spleen Morphology in Lean, but not, in Monosodium-Glutamate-Obese Rats

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Changes in Adult Rats’ Testis structure Induced by Hypothyroidism and Alleviating Role of L-Carnitine

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Effect of a High Fat and High Protein Diet on Exercise-Induced Skeletal Muscle Hypertrophy in Rats

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The Effect of Aqueous Extract of Ocimum gratissium (Linn) on 1, 2 - Dimethyl Hydrazine induced Colon Cancer in Male Wistar Rats

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Auricularia Polytricha (Mushroom) Regulates Testicular DNA Expression and Oxidative Stress Markers of Streptozotocin-Induced Diabetic Male Wistar Rat

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Effects of Aluminium Sulphates on Weight and Structure of Adrenal Gland of Adult Wistar Rats

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Effects of Selected Secondary Metabolites in Leaf Extract of Jatropha Tanjorensis on Some Gonadal Hormones in Male Wistar Rats

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Prevention of Aging and Improvement of Longevity and Life-Span in D-Galactose Induced Aging Rats After Treatment with the Biofield Energy Per Se and Biofield Treated Proprietary Test Formulation

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Evaluation of Biological Activities of Opuntia Ficus Indica Cladodes Extract Against Cadmium-Induced Osteoporosis in Male Wistar Rats

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Effect of Trigonella Foenum against Ethylene Diamine Tetra Acetic Acid induced Nephrotoxicity in Male Albino Rats

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Biological Effects of High Radiofrequency Radiation on Wistar Rats: A Literature Review

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Effect of Wheat Germ, Wheat Germ Oil on Lipid Profile of Hypercholesterolemic Rats

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Evaluation of Anti-oxidation and Therapeutic Effect of Biofield Energy Healing Based Novel Test Formulation Using TNBS (Tri Nitro Benzene Sulfonic Acid) - Induced Ulcerative Colitis in Sprague Dawley Rats

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Evaluation of Vitamin D3 metabolite (25-OH Vit D3), Neurotransmitter (ACh), and the Expression of Proinflammatory Cytokines (IL-6 and TNF-α) in Tissue Homogenate after Administration of Biofield Energy Healing-based Novel Proprietary Test Formulation and Biofield Treatment per se to the Animals in Vitamin D3 Deficiency Diet (VDD)-induced Sprague Dawley Rats

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Antioxidant Activity of Biofield Treated Proprietary Test Formulation Supplemented with Vitamins and Minerals in Vitamin D3 Deficiency Diet (VDD) Induced Sprague Dawley Rats

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Evaluation of Renal and Cardioprotective Potential of the Biofield Energy Treated Proprietary Test Formulation on L-NAME and High Fat Diet-Induced Cardiovascular Disorders in Sprague Dawley Rats

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Evaluation of Immunomodulatory Effect of a Novel Test Formulation in D-Galactose-Induced Aging Dysfunction in Sprague Dawley Rats

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Evaluation of Antioxidative Potential of the Biofield Energy Treated Proprietary Test Formulation on L-NAME and High Fat Diet-Induced Cardiovascular Disorders in Sprague Dawley Rats

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Evaluation of Cardiac Performance after Treatment with the Biofield Energy Treated Proprietary Test Formulation on L-NAME and High Fat Diet-Induced Cardiovascular Disorders in Sprague Dawley Rats

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Antioxidant and Anti-Inflammatory Activities of Biofield Energy Treated Proprietary Test Formulation in Brain Tissues in Cecal Slurry, LPS and E. Coli-Induced Systemic Inflammatory Response Syndrome (SIRS) in Sprague Dawley Rats

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Evaluation of Inflammatory Serum Cytokines after Treatment with the Consciousness Energy Healing Based Proprietary Test Formulation on Combination of Cecal Slurry, LPS and E. Coli Induced Systemic Inflammatory Response Syndrome (SIRS) in Sprague Dawley Rats

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Evaluation of Antioxidative Potential of the Biofield Energy Treated Proprietary Test Formulation on L-NAME and High Fat Diet-Induced Cardiovascular Disorders in Sprague Dawley Rats

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Effect of Extracts of Dialium guineense Stem Bark on Lipid Profile and CCl4- Induced Histological Changes in Liver of Wistar Rats

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Histomorphomertric Analysis Of Hormonal Contraceptive Pills On Anterior Pituitary Gland In Female Wister Rats

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Pain Perception Modulates Synaptic and Somatic Plasticity in the Dentate Gyrus of Rats

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