Overview
Animal models are living non-human organisms used in research to represent biological processes, disease states, and responses to intervention that are relevant to human or veterinary health. In pharmaceutical science they are central to evaluating the efficacy, mechanism, pharmacokinetics, and toxicology of candidate drugs and treatments under controlled conditions before clinical testing. Commonly used species include rodents and other mammals selected for their physiological similarity to humans, tractable husbandry, and, where appropriate, genetic modification that recapitulates specific pathology. Research in this area employs animal models to assess the histomorphological and physiological effects of plant extracts, to develop and test formulations such as neuroprotective agents, to evaluate analgesic and anti-inflammatory candidates, and to investigate interventions ranging from deep-brain stimulation for epilepsy to imaging-agent development and gene therapy. Such models also support biomarker discovery and the study of inflammation and infection. Their use is governed by ethical principles emphasising refinement, reduction, and replacement, and is increasingly complemented by in vitro and in silico disease models. Animal models matter because they bridge molecular and cellular findings and clinical translation, providing systems in which safety and efficacy can be examined at the level of the whole organism. The journal publishes peer-reviewed research employing animal models to address pharmacological, toxicological, and pathophysiological questions.
Research published in this journal
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
How this research is being cited
The 12 articles above have been cited 31 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2023 · Journal of Computational Biophysics and Chemistry
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2023 · Journal of Computational Biophysics and Chemistry
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Fang Zhang et al. · 2021 · Frontiers in Neurology
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Cell Therapy as an Alternative approach for COVID-19 Infection Consequences: A Non-Systematic Review2021 · International Journal of Coronaviruses
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2021 · Neuroscience Letters
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2021 · Frontiers in Neurology
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2021 · Neuroscience Letters
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Cell Therapy as an Alternative approach for COVID-19 Infection Consequences: A Non-Systematic Review2021 · International Journal of Coronaviruses
A sample of recent works citing this journal's research on Animal Models, linking to each citing work.