Pyruvate

Dehydrogenase Pyruvate Dehydrogenase (PDH) is an enzyme that plays an essential role in the metabolism of glucose. It is the primary enzyme responsible for the conversion of pyruvate, a product of glycolysis, into Acetyl-CoA, which enters the Krebs cycle to produce energy in the form of ATP. PDH is also involved in numerous other biochemical pathways related to energy production and storage, protein and lipid metabolism, and various other metabolic pathways. As such, it plays a pivotal role in the body’s energy production and storage processes. Defects in PDH can lead to serious metabolic disorders including lactic acidosis, neurodegenerative diseases, and anaemia. Therefore, PDH is an important enzyme for understanding the various biochemical processes that regulate energy metabolism and storage.