Pathogenesis of Parkinson?s Disease
Parkinson’s disease (PD) is a progressive neurological disorder caused by the loss of cells in the substantia nigra, a region of the brain that is responsible for producing dopamine. As a result of this loss, dopamine levels become depleted, leading to an imbalance in motor control, resulting in the characteristic tremors, stiffness and slow movement associated with PD. The exact cause of PD is unknown, however a combination of environmental and genetic factors are thought to be involved in the pathogenesis of the disorder. Research has suggested that oxidative stress and inflammation could be linked to the development of PD, and drugs that target these mechanisms can be used to help manage symptoms. In addition, research has suggested that lifestyle factors, such as exercise and a healthy diet, may be beneficial in preventing or delaying the onset of PD.
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