Transgenic Mice

Overview

Transgenic mice are laboratory mice whose genome has been deliberately altered through the introduction, modification, or deletion of specific genes, making them indispensable models for studying gene function, disease mechanisms, and candidate therapies in a living mammalian system. They are generated by introducing exogenous DNA into the germline—classically through pronuclear microinjection or embryonic stem-cell manipulation—so that the engineered sequence is heritable and expressed in defined tissues. By enabling controlled gain- or loss-of-function, tissue-specific and inducible expression, and the humanization of particular loci, transgenic mice allow investigators to dissect the contribution of individual genes to physiology and pathology and to evaluate interventions before clinical translation. They have transformed biomedical research across immunology, oncology, metabolism, and neuroscience. The peer-reviewed research in this area includes work using transgenic mice and related models, such as analysis of the alveolar macrophage proteome in transgenic mice expressing human surfactant proteins SP-A1 and SP-A2, investigations of adipose-tissue physiology relevant to obesity, perspectives on the scope and future of experimental zoology, and discussion of gene-therapy strategies for heart failure. Recurring themes include the use of genetically defined animals to model human biology, the study of proteomic and physiological consequences of targeted genetic changes, and the role of engineered mice in linking gene function to disease and therapeutic development.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue
  2022 · Scientific Reports
• The ultrastructural heterogeneity of lung surfactant revealed by serial section electron tomography: insights into the 3-D architecture of human tubular myelin
  2022 · American Journal of Physiology-Lung Cellular and Molecular Physiology
• Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection
  2022 · Frontiers in Immunology
• How cell migration helps immune sentinels
  2022 · Frontiers in Cell and Developmental Biology
• The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0)
  2022 · Frontiers in Immunology
• A Pilot Proteomic Study of Vestibular Fluid From Patients With Vulvodynia
  2022 · Journal of Lower Genital Tract Disease
• Efeitos da ingestão do suco de laranja Pera e suco de laranja Moro na microbiota intestinal e marcadores inflamatórios em indivíduos com obesidade
  2021 ·
• Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions
  2021 · Frontiers in Immunology

A sample of recent works citing this journal's research on Transgenic Mice, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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