DNA Sequencing

Overview

DNA sequencing is the determination of the precise order of the four nucleotide bases—adenine, thymine, guanine, and cytosine—along a DNA molecule, providing the foundational data for genetics, genomics, and molecular medicine. Methods range from chain-termination chemistry to massively parallel high-throughput platforms, and the resulting sequences are used to identify genes, characterize variation between individuals, detect disease-associated mutations, and reconstruct evolutionary relationships. Sequencing enables comparative genomics, molecular phylogenetics, pathogen typing, and the interpretation of single-nucleotide polymorphisms that influence drug response and disease susceptibility, with downstream analysis relying on bioinformatic alignment, variant calling, and annotation. The peer-reviewed research in this area applies sequencing and sequence-based analysis across diverse problems, including proteomic and genomic techniques in cancer and personalized medicine, characterization of rpoB mutations underlying rifampicin resistance in multidrug-resistant tuberculosis, comparative analysis of primate chromosomes, screening for catalase-gene polymorphisms, single-nucleotide-polymorphism profiling to individualize immunosuppressive therapy, identification of somatic mutations in interferon-gamma signaling molecules in uterine leiomyosarcoma, the role of human papillomavirus in carcinogenesis, and DNA barcoding to determine the food-plant resources of field-mouse populations. Recurring themes include variant and mutation detection, the use of sequence data for molecular diagnosis and resistance profiling, comparative and evolutionary genomics, species identification through barcoding, and the integration of sequencing with proteomic and clinical information to advance precision medicine.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 45 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Sample Size Calculation in Genetic Association Studies: A Practical Approach
  2023 · Life
• Sample Size Calculation in Genetic Association Studies: A Practical Approach
  2023 · Life
• The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue
  2022 · Scientific Reports
• The ultrastructural heterogeneity of lung surfactant revealed by serial section electron tomography: insights into the 3-D architecture of human tubular myelin
  2022 · American Journal of Physiology-Lung Cellular and Molecular Physiology
• Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection
  2022 · Frontiers in Immunology
• How cell migration helps immune sentinels
  2022 · Frontiers in Cell and Developmental Biology
• The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0)
  2022 · Frontiers in Immunology
• A Pilot Proteomic Study of Vestibular Fluid From Patients With Vulvodynia
  2022 · Journal of Lower Genital Tract Disease

A sample of recent works citing this journal's research on DNA Sequencing, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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