Osteoblasts

Osteoblasts are cells responsible for the formation of bones. They are the most important active players in the process of bone formation and remodeling. Osteoblasts produce the extracellular matrix that serves as the base for new bone formation, and release growth factors, cytokines and hormones that regulate bone metabolism and homeostasis. Osteoblasts are the key players in calcium and phosphorus balance, which are essential for the long-term health of bones, muscles and other organs. Osteoblasts play an important role in maintaining skeletal integrity, and their activity is closely linked to the proper functioning of the endocrine system. A wide range of diseases, from osteoporosis to Paget's disease and osteogenesis imperfecta, can be caused by defects in the development and function of osteoblasts. Research into osteoblasts is therefore highly beneficial for establishing better treatments and preventive strategies for a variety of bone-related diseases.