Research Topic · Peer-Reviewed

Papillary Thyroid Cancer

Papillary Thyroid Cancer (PTC) is the most common malignancy of the thyroid gland, a well-differentiated carcinoma arising from follicular epithelial cells and characterized histologically by distinctive papillary architecture, overlapping ground-glass ("Orphan Annie eye") nuclei, nuclear grooves, and psammoma bodie…

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 21× across the literature 🔖 ISSN 2574-4496 🗓 Reviewed July 2026

Overview

Papillary Thyroid Cancer (PTC) is the most common malignancy of the thyroid gland, a well-differentiated carcinoma arising from follicular epithelial cells and characterized histologically by distinctive papillary architecture, overlapping ground-glass ("Orphan Annie eye") nuclei, nuclear grooves, and psammoma bodies. It typically grows slowly, has a marked tendency toward lymphatic spread to regional cervical nodes, and generally carries a favorable prognosis. Diagnosis relies on ultrasonography, fine-needle aspiration cytology, and increasingly on molecular characterization of driver alterations such as BRAF and RAS mutations and RET rearrangements, which refine risk stratification and inform management. Because PTC retains features of normal thyroid biology, including iodine avidity and dependence on transcription factors governing thyroid-cell proliferation, treatment is built around total or partial thyroidectomy followed, in selected cases, by radioactive iodine ablation and thyroid-stimulating-hormone-suppressive therapy, with long-term surveillance using thyroglobulin and imaging. The articles assembled here address Thyroid Cancer diagnosis and molecular workup, surgical and radioiodine treatment outcomes over extended follow-up, incidence trends in defined populations, image-guided ablation, the role of thyroid transcription factor-1 in tumor-cell proliferation, and trace-element composition of malignant nodules, together reflecting the diagnostic, molecular, surgical, and radioisotopic dimensions central to managing differentiated thyroid carcinoma.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Image Guided Ablations for Thyroid Tumours

Nicosia LucaCorresponding author
Division of Breast Radiology, European Institute of Oncology IRCCS, Milan, Italy, European Institute of Oncology IEO, IRCCS, Via Giuseppe Ripamonti, 435 - 20141 Milano MI, Italy
Thyroid Cancer Cited by 2 doi:10.14302/issn.2574-4496.jtc-19-2657
2018

In The Pursuit of The Perfect Thyroid Care

Kumar Sahoo ManasCorresponding author
Consultant Nuclear Medicine & PET/CT, Department of Nuclear Medicine &PET-CT. Medanta-The Medicity, Gurugram, India.
Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-18-1986

How this research is being cited

The 10 articles above have been cited 21 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Papillary Thyroid Cancer, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thyroid Cancer (ISSN 2574-4496).

Journal editorial board
Giovanni Mauri · Italy Pamela Pinzani · Italy Byeong-Cheol Ahn · South Korea

This page summarises published research for orientation; it is not medical or professional advice.