Research Topic · Peer-Reviewed

Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of conditions defined by excessive accumulation of triglyceride within hepatocytes in the absence of significant alcohol consumption or other secondary causes of steatosis. It ranges from simple steatosis through nonalcoholic steatohepatitis, in which fat deposi…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 17× across the literature 🔖 ISSN 2578-2371 🗓 Reviewed July 2026

Overview

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of conditions defined by excessive accumulation of triglyceride within hepatocytes in the absence of significant alcohol consumption or other secondary causes of steatosis. It ranges from simple steatosis through nonalcoholic steatohepatitis, in which fat deposition is accompanied by hepatocellular injury, inflammation, and progressive fibrosis that can advance to cirrhosis and hepatocellular carcinoma. NAFLD is closely coupled to insulin resistance and the metabolic syndrome, and shares risk factors with obesity and type 2 diabetes, making it a hepatic manifestation of systemic metabolic dysfunction. Pathogenesis involves an interplay of excess substrate delivery, impaired lipid handling, oxidative stress, and inflammatory signalling, situating the disorder within the broader landscape of chronic liver disease whose magnitude and clinical burden have been documented in hospital-based studies. Nutritional and endocrine factors strongly modulate its course: vitamin D deficiency is common in chronic liver disease and carries clinical significance, thyroid hormone status contributes adaptively to obesity, and dietary composition, including protein intake and its effect on fat mass in obese adolescents with and without type 2 diabetes, influences metabolic risk. Diagnosis combines liver biochemistry, imaging, and where indicated histology, while management emphasises weight reduction, glycaemic and lipid control, and nutritional intervention to limit progression.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Adaptive Contribution of Thyroid Hormones in Obesity

Ozcelik FatihCorresponding author
University of Health Sciences, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey
Exact topic International Journal of Negative Results Cited by 2 doi:10.14302/issn.2641-9181.ijnr-18-2530

How this research is being cited

The 6 articles above have been cited 17 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Nonalcoholic Fatty Liver Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Spleen And Liver Research (ISSN 2578-2371).

Journal editorial board
Florin Graur · Romania

This page summarises published research for orientation; it is not medical or professional advice.