Research Topic · Peer-Reviewed

Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions characterized by excess accumulation of fat in hepatocytes in the absence of significant alcohol consumption. It ranges from simple steatosis, in which fat deposits without marked inflammation, to non-alcoholic steatohepatitis, in wh…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 20× across the literature 🔖 ISSN 2578-2371 🗓 Reviewed July 2026

Overview

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions characterized by excess accumulation of fat in hepatocytes in the absence of significant alcohol consumption. It ranges from simple steatosis, in which fat deposits without marked inflammation, to non-alcoholic steatohepatitis, in which steatosis is accompanied by inflammation and hepatocellular injury that can progress to fibrosis, cirrhosis, and hepatocellular carcinoma. The disease is closely linked to obesity, insulin resistance, type 2 diabetes, and dyslipidemia, and is regarded as the hepatic manifestation of metabolic syndrome. Its pathogenesis involves disturbed lipid handling, mitochondrial dysfunction, oxidative stress, and inflammatory signaling, with nutritional and epigenetic factors shaping individual susceptibility and progression. Within the broader landscape of chronic liver disease, NAFLD contributes substantially to the burden documented in hospital-based studies of liver disease, alongside viral and other etiologies, and its complications include portal hypertension and decompensation assessed through measures of liver stiffness. Diagnosis relies on imaging, elastography, liver enzymes, and exclusion of competing causes, while management centers on weight reduction, dietary modification, control of metabolic risk factors, and emerging pharmacological and network-pharmacology-guided therapeutic targets. Because it is among the most common chronic liver disorders and is rising with metabolic disease, NAFLD is a major focus of hepatology, nutrition science, and metabolic medicine.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 9 articles above have been cited 20 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Non-Alcoholic Fatty Liver Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Spleen And Liver Research (ISSN 2578-2371).

Journal editorial board
Florin Graur · Romania

This page summarises published research for orientation; it is not medical or professional advice.