Fibrinogen

Fibrinogen is an important plasma protein essential for the formation of blood clots. It is synthesized in the liver and circulates in the bloodstream. When a blood vessel is damaged, fibrinogen is activated and undergoes a series of transformations that form a network of fibrin strands, which create a scaffold to entrap platelets and red blood cells. This scaffolding traps clotting factors and forms a stable clot that is able to restore tissue integrity and prevent further damage. Fibrinogen is a crucial component of the clotting cascade, and it is essential for hemostasis. Fibrinogen concentrations are decreased in a range of medical conditions, including liver and kidney diseases, as well as in certain trauma and sepsis cases. Fibrinogen supplementation is used to control bleeding in these settings.