Chemotherapy

Overview

Chemotherapy is the systemic use of cytotoxic and related drugs to treat cancer by killing malignant cells or arresting their proliferation. It acts on processes essential to rapidly dividing cells, including DNA replication, mitosis, and repair, and is administered as curative, adjuvant, neoadjuvant, or palliative treatment, frequently in defined regimens and in combination with surgery, radiotherapy, immunotherapy, or targeted agents. Because many normal tissues also proliferate, toxicity and the balance of efficacy against adverse effects are central considerations, as are resistance and treatment sequencing. Research in this area examines chemotherapy across malignancies, including its role following whole-brain radiotherapy as a prognostic factor in metastatic breast cancer, the management of locally advanced and metastatic pediatric nasopharyngeal carcinoma, and the efficacy of targeted antibody therapy such as trastuzumab in HER2-positive gastric cancer. Studies address chemotherapy-associated complications, including progressive multifocal leukoencephalopathy during lymphoma treatment, and supportive interventions such as stem-cell mobilization. Broader oncological context includes survival among breast-cancer patients, treatment of head-and-neck and lymphoid malignancies, psychological care during cancer treatment, and conceptual perspectives on cancer biology and complementary approaches. By connecting drug mechanisms, regimens, and clinical outcomes, the field informs cancer management. The journal publishes peer-reviewed research relevant to chemotherapy, its applications, complications, and integration within multimodal cancer care.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 16 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer
  Jaekwon Seok et al. · 2023 · Journal of Translational Medicine
• J591 functionalized paclitaxel loaded PLGA nanoparticles successfully inhibited PSMA overexpressing LNCaP cells
  Iman Ehsan et al. · 2022 · Journal of Drug Delivery Science and Technology
• Pediatric Nasopharyngeal Carcinoma: A Rare Tumor in a Developing Country—What Do We Learn?
  2020 · Journal of Pediatric Hematology/Oncology
• Excerpts from Flaws in Medicine Must Be Corrected: An Open Report to National Governments Amid the Pandemic
  2020 ·
• Surgeon work captured by the National Surgical Quality Improvement Program across specialties
  2019 · Surgery
• Complementary and Alternative Treatments for Cancer Prevention and Cure (Part 1)
  2019 · Journal of Experimental and Clinical Toxicology
• Surgeon work captured by the National Surgical Quality Improvement Program across specialties.
  Amber B. Tang et al. · 2019 · Surgery
• Pediatric Nasopharyngeal Carcinoma: A Rare Tumor in a Developing Country—What Do We Learn?
  2019 · Journal of Pediatric Hematology/Oncology

A sample of recent works citing this journal's research on Chemotherapy, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

Related topics