Safety studies are investigations designed to identify, quantify, and characterise the potential harms of medical, pharmaceutical, environmental, and occupational exposures so that risks can be weighed against benefits. They range from preclinical toxicity testing, including in vitro disease models and animal studie…
Safety studies are investigations designed to identify, quantify, and characterise the potential harms of medical, pharmaceutical, environmental, and occupational exposures so that risks can be weighed against benefits. They range from preclinical toxicity testing, including in vitro disease models and animal studies used to screen drugs and substances before human use, to clinical and epidemiological research that monitors adverse effects, hypersensitivity, and injury patterns in defined populations. In drug safety, this work includes assessing organ-specific toxicity such as cardiotoxicity, and evaluating the risk of cross-reactivity among related medicines, for example among nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors in patients with hypersensitivity. In environmental and public-health safety, studies examine the histological and physiological effects of substances in animal models and document the burden and management of injuries, such as unintentional injuries in young children. Safety research also extends to systems and the people who run them, including the patient-safety consequences of clinician burnout and the programmatic interventions that mitigate it. Methods include toxicological assays, controlled experiments, surveillance, observational cohorts, and systematic review of the existing evidence base. By generating reliable evidence on harm, safety studies underpin regulatory approval, clinical guidelines, pharmacovigilance, and preventive policy, ensuring that interventions and exposures are evaluated for risk rather than efficacy alone.
5 peer-reviewed articles, ranked by relevance. Each links to its DOI.
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