Sanford Burnham Medical Research Institute.
10901 N Torrey Pines Road,
Innovations in high throughput screening platforms Proteomic and Genetic screens Innate Immune Mechanisms Host-pathogen interactions modulation of host cell signaling by virulence factors
- I am an experienced researcher in the field of infectious disease biology and Immunology, who is passionate about conducting research that improves existing technologies while also developing novel approaches to generate therapeutic measures targeting major health disorders/diseases worldwide.
- I have over 12 years of experience in leveraging cell biology tools and cutting edge high throughput genetic and proteomic technologies to manipulate cellular components and signaling mechanisms in order to identify critical regulators of bacterial and viral (HIV) infections.
- As a post-doctoral researcher at Sanford Burnham Medical Research Institute (San Diego, CA), I have used systems biology and biochemical approaches to identify novel immune mediators that restrict HIV infection.
- Using High throughput platforms for antiviral target identification, I have successfully developed a new platform that utilizes High content Imaging based proteomic screen to identify host immune factors that restrict HIV infection.
- Additionally, my research also leverages high throughput siRNA based genetic screens to tease out critical innate immune anti-viral mechanisms.
- I have considerable experience in the application of a vast array of relevant statistical measures that are critical in the identification of true 'hits' and weeding off of false positives within large data sets typically generated in genetic and proteomic screens.
- As a graduate researcher at the University of Illinois (Urbana-Champaign), I identified novel bacterial strategies that rely on co-opting or modulating cellular signaling processes to subvert host immune mechanisms.
- Here, I initiated a study to evaluate the active remodeling of cellular mitochondrial network by secreted bacterial toxins.
- My research identified the importance of mitochondrial network dynamics as well as protein complexes involved in cell death mechanism in the control of bacterial infection and long term persistence.
- It has been my passion to conduct studies that are innovative, as well as sufficiently informative to shepherd future discovery efforts focusing on identification of broad and effective therapeutic targets against major diseases worldwide.
- I have been fortunate to collaborate with researchers from several leading institutions in the US as a part of the HIV Immune Networks Team (hint.org) and present my research findings in major international meetings.