Array CGH

Array Comparative Genome Hybridization (Array CGH) is a laboratory technique used to detect genetic alterations in the genomic DNA of an organism. The technique makes use of a microarray platform to measure the amount of DNA present in a sample at any given location of the genome. Array CGH is a powerful tool for diagnosing genetic abnormalities associated with congenital and hereditary disorders, cancer, and other genetic diseases. Array CGH can also be used for making gene-expression profiles in cells, microbial genomic analysis, and population-level studies. Its high-resolution and high-throughput capacity make it a useful tool for identifying subtle variations in the genome, including point mutations, oblique insertions and deletions, gene rearrangements and copy number variation. Array CGH is widely used in research and clinical settings, and its importance in mapping out the functions of the human genome will continue to increase in the years to come.