A monoclonal antibody is an immunoglobulin produced by a single clone of B cells, so that all molecules are identical and recognize a single epitope on a target antigen with defined specificity and affinity. Originally generated by hybridoma technology fusing antibody-producing cells with immortalized myeloma cells,…
A monoclonal antibody is an immunoglobulin produced by a single clone of B cells, so that all molecules are identical and recognize a single epitope on a target antigen with defined specificity and affinity. Originally generated by hybridoma technology fusing antibody-producing cells with immortalized myeloma cells, monoclonal antibodies are now also derived by recombinant methods including phage display and single-chain variable fragment (scFv) engineering, and are produced as chimeric, humanized, or fully human formats to reduce immunogenicity. Their precise targeting makes them indispensable as research and diagnostic reagents and as therapeutics in oncology, autoimmunity, inflammation, and infectious disease, acting through neutralization, immune-cell recruitment, or blockade of signaling and immune-checkpoint pathways. Engineered derivatives include bispecific antibodies and antibody-based receptor probes. Research relevant to this area examines isolation of a human scFv antibody recognizing a serotonin-receptor heteromer, neutralizing antibodies in convalescent immune plasma against SARS-CoV-2, immunodetection of cellular markers in tumor aggressiveness, checkpoint blockade of the programmed cell death protein-1 pathway in melanoma, proteomic responses to targeted antibody therapy, and laboratory tests used in immune thrombocytopenia. This peer-reviewed literature reflects the generation, engineering, and therapeutic and diagnostic application of monoclonal antibodies across biomedical research, situating antibody technology within the broader study of immunology and targeted therapy.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 53 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Monoclonal Antibody, linking to each citing work.