Histocompatibility

Testing Histocompatibility testing is a laboratory procedure used to determine if a potential donor’s organs or tissue are compatible with a potential recipient. The testing is based on the detection of antigens called Human Leukocyte Antigens (HLAs) which are inherited markers found on the surface of cells in the body. HLAs vary from person to person and by comparing HLAs between the two individuals, the likelihood of a successful transplant can be accurately determined. This test is of great importance in organ transplants and blood transfusions, ensuring that the donor and recipient are well matched and increasing the chances of a successful transplant or transfusion. Histocompatibility testing is also used in the fields of immunogenetics, forensic science, paternity testing, and in the study of inherited diseases.