Gap Junctions
Gap junctions are specialized intercellular proteins that enable direct communication between neighboring cells. They are important for many cellular functions and processes, such as tissue development, signaling, metabolism, and cell differentiation. Gap junctions are made up of connexins, which are integral membrane proteins that form channels through which ions and small molecules can pass. The channels regulate the flow of calcium, potassium and other small molecules between cells, allowing cells to coordinate their activities and enabling them to communicate with each other. Gap junctions are involved in numerous physiological processes and have been implicated in various diseases. They are essential for the correct functioning of the cardiovascular system, development, fertility, and neoplastic transformation. Gap junctions are important regulators of cell-cell communication and are potential targets for drug therapy.
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