Stereoselectivity refers to the preferential formation of one stereoisomer over others during a chemical reaction, a fundamental concept in synthetic chemistry where the three-dimensional arrangement of atoms significantly affects molecular properties and biological activity. Research published in New Developments i…
Stereoselectivity refers to the preferential formation of one stereoisomer over others during a chemical reaction, a fundamental concept in synthetic chemistry where the three-dimensional arrangement of atoms significantly affects molecular properties and biological activity. Research published in New Developments in Chemistry addresses stereoselectivity primarily in the context of nucleoside analogue synthesis and carbohydrate chemistry. Studies have examined the stereoselective synthesis of modified purine nucleosides including 2-chloro-2′-deoxyadenosine and related analogues, where control of stereochemistry at specific positions is essential for producing compounds with desired biological properties. Additional work has focused on C2′-β-fluorinated nucleoside analogues such as clofarabine, demonstrating methods to achieve selective introduction of fluorine atoms in defined stereochemical configurations. Research on carbohydrate transformations has explored stereoselective formation of N-glycosyl amides through controlled hydrolysis and Ritter-like reactions, highlighting the importance of stereochemical control in glycoside bond formation. The topic matters because stereoisomers can exhibit dramatically different pharmacological activities, and the ability to selectively synthesize specific stereoisomers is crucial for developing effective therapeutic agents and understanding structure-activity relationships in medicinal chemistry and biochemistry.
4 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 4 articles above have been cited 7 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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