Research Topic · Peer-Reviewed

Pyruvate

Pyruvate is the conjugate base of pyruvic acid, a three-carbon alpha-keto carboxylic acid that occupies a central position in cellular metabolism. It is the terminal product of glycolysis, where one molecule of glucose is oxidized to two molecules of pyruvate with net production of ATP and NADH. The metabolic fate o…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 61× across the literature 🔖 ISSN 2377-2549

Overview

Pyruvate is the conjugate base of pyruvic acid, a three-carbon alpha-keto carboxylic acid that occupies a central position in cellular metabolism. It is the terminal product of glycolysis, where one molecule of glucose is oxidized to two molecules of pyruvate with net production of ATP and NADH. The metabolic fate of pyruvate depends on cellular oxygen status and redox balance: under aerobic conditions the pyruvate dehydrogenase complex oxidatively decarboxylates it to acetyl-CoA for entry into the citric acid cycle, whereas under anaerobic or high-flux conditions lactate dehydrogenase reduces it to lactate, regenerating NAD+ and influencing acid-base homeostasis. Pyruvate also serves as a substrate for gluconeogenesis via carboxylation to oxaloacetate and for transamination to alanine, linking carbohydrate and amino acid metabolism. Its concentration relative to lactate reports on tissue oxygenation and is relevant to conditions such as lactic acidosis, while metabolomic profiling tracks pyruvate alongside other intermediates to characterize metabolic perturbation. New Developments in Chemistry publishes peer-reviewed research touching on pyruvate metabolism and related bioenergetics, including its clinical research outlooks, the biochemistry of lactic acidosis, and metabolomic analyses of energy intermediates in biological systems.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 61 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Pyruvate, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Zhe-Sheng Chen · United States Abel Jose de Sousa Costa Vieira · Portugal Amirhassan Amiri · Iran, Islamic Republic of

This page summarises published research for orientation; it is not medical or professional advice.