Research Topic · Peer-Reviewed

Protein Structure

Protein structure is the three-dimensional arrangement of atoms in a protein molecule, which determines its biological function. It is described at four hierarchical levels: the primary structure, or linear sequence of amino acids linked by peptide bonds; the secondary structure of local folding motifs such as alpha…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 41× across the literature 🔖 ISSN 2377-2549

Overview

Protein structure is the three-dimensional arrangement of atoms in a protein molecule, which determines its biological function. It is described at four hierarchical levels: the primary structure, or linear sequence of amino acids linked by peptide bonds; the secondary structure of local folding motifs such as alpha-helices and beta-sheets stabilized by hydrogen bonds; the tertiary structure, the overall folded conformation of a single chain stabilized by hydrophobic packing, disulfide bonds, and other interactions; and the quaternary structure formed by the assembly of multiple subunits. Folding is dictated by the amino acid sequence and is essential for catalysis, molecular recognition, signaling, and structural roles, whereas misfolding and destabilizing variants contribute to disease. Structure is elucidated and analyzed by experimental methods and by computational and bioinformatic approaches, including domain analysis, molecular modeling, and in silico studies of protein targets, and structural insight guides drug design and protein engineering. The research reflected here includes characterization of DNA-binding protein domains and disulfide-mediated dimerization, proteome and bioinformatics analyses, phylogenetic and domain-conservation studies of RNA-binding proteins, in silico inhibition of microbial proteins, structural-functional analysis of disease-associated variants, and solid-phase peptide synthesis. The journal publishes peer-reviewed studies on protein structure, folding, structural bioinformatics, and structure-function relationships.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Protein Structure, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Zhe-Sheng Chen · United States Abel Jose de Sousa Costa Vieira · Portugal Amirhassan Amiri · Iran, Islamic Republic of

This page summarises published research for orientation; it is not medical or professional advice.