Protein Aggregation

Protein aggregation is a growing area of interest in the field of chemistry, particularly in the study of protein structure and function. As the building blocks of all organisms, proteins are essential for life, and scientists are constantly working to understand how they work and how they can be manipulated for therapeutic purposes. Protein aggregation refers to the process by which proteins come together to form larger complexes or aggregates. This can happen for a number of reasons, including changes in the protein’s environment or chemical modifications. When proteins aggregate, they can form harmful clumps or plaques that interfere with their normal function, leading to disease. Recent developments in chemistry have shed new light on the mechanisms behind protein aggregation, and have opened up new avenues for research into preventing or reversing this process. Scientists are exploring various methods for stabilizing proteins and preventing aggregation, including using small molecule inhibitors and chaperone proteins. Understanding the causes and effects of protein aggregation is crucial for the development of new therapies for a range of diseases, including Alzheimer’s disease, Parkinson’s disease, and cystic fibrosis. By shedding light on the molecular processes involved in these diseases, scientists hope to develop more effective treatments and ultimately improve the lives of patients. As research in this field continues to expand, it is likely that we will see further breakthroughs and new discoveries in the years to come.

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29 article(s) found
Eukaryotic Signature Proteins
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Substrate Stiffness Influences the Time Dependence of CTGF Protein Expression in Müller Cells
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Human Myxomatous Mitral Valves Exhibit Focal Expression of Cartilage-Related Proteins
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Heart-Type Fatty Acid-Binding Protein Enables Rapid Risk Stratification in Patients with Pulmonary Embolism
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Etodolac, A Preferential COX-2 Inhibitor, does not Inhibit Platelet Aggregation in a Randomized Placebo-Controlled Trial
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Correlation of Cryptococcal Antigen Assay with C-reactive Protein as Serum and Urine Biomarker in Cryptococcal Meningitis: Experience in a Tertiary Hospital
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Daily Saliva and Vaginal Mucins Co-vary in Protein-to-Carbohydrate Ratio
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Proteome and Proteomics: from Single Protein to Whole Body
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Correlation of Oncotype DX Recurrence Score with the Expression of Insulin Receptor Substrate Proteins in Estrogen Receptor + Breast Cancer
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Overexpression of Prostate Apoptosis Response Protein-4 In Colon Cancer Cells Can Inhibit Metastasis by Upregulating E-cadherin Expression
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Investigations of Molecular Evolutionary Mechanisms in Partially Sequenced Heat Shock Protein70 Homologue-Coding Gene of Olive Leaf Yellowing-Associated Virus Isolates from Tunisia
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A Pilot Study Assessing the Impact of a High Protein Supplementation Diet on Fat Mass in Obese Adolescents with and without Type 2 Diabetes
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Bioinformatic Analysis of Coronary Disease Associated SNPs and Genes to Identify Proteins Potentially Involved in the Pathogenesis of Atherosclerosis
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Total Proteins, β- and γ-globulins as efficacy therapy response indicators in dogs infected with Leishmania infantum – a Review
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Blockade of Programmed Cell Death Protein-1 Pathway for the Treatment of Melanoma
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Metal Metalloproteinase 2 is Differentially Regulated by the Interplay between Glucose and Insulin
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In Silico Inhibition of Essential Candida albicans Proteins by Arenicin, a Marine Antifungal Peptide
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Record of Aggregation of Alien Tropical Schyphozoan Rhopilema nomadica Galil, 1990 in the Mediterranean Coast of Egypt
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Adrenomedullin as a Protein with Multifunctional Behavior and Effects in Various Organs and Tissues
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Alpha-Fetoprotein and its Receptor: More Than Oncofoetal Antigens.
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Effect of a High Fat and High Protein Diet on Exercise-Induced Skeletal Muscle Hypertrophy in Rats
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Survival Rate and Growth Performances on Pre-Grossing of the African Cyprinidae LabeobarbusBatesii (Boulenger, 1903) According to the Level of Dietary Protein
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Molecular Evolutionary Characteristics of the 2019 Novel Coronavirus (SARS-CoV-2) Contracted by Tunisian Citizens : Comparison and Relationship to Other Human and Animal Coronaviruses Based on Spike Glycoprotein-Coding Gene Sequences Analysis
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Modeling of the Deposition of Low-Density Lipoprotein Particles inside an Ideal Geometry of the Heart Coronary Arteries
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Marginal SARS-CoV-2 Spike Protein Increases Interferon and Balances Cytokine Gene Expression
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Functional properties of Watermelon (Citrullus lanatus) and Pumpkin seed flours and protein isolate
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Effect of Protein and Energy-Dense Nutritional Supplement with Immunonutrients on Cachexia in Cancer Patients: An Open-Label, Single-Arm Study Among Indian Patients
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Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa
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Understanding Inherited Bleeding Disorders: Genetic Mutations in Blood Coagulation Factors and Regulatory Proteins
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